Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease
Identifieur interne : 002889 ( Main/Corpus ); précédent : 002888; suivant : 002890Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease
Auteurs : Lindsy N. Williams ; Paul Seignourel ; Gregory P. Crucian ; Michael S. Okun ; Ramon L. Rodriguez ; Frank M. Skidmore ; Paul S. Foster ; Charles E. Jacobson Iv ; Janet Romrell ; Dawn Bowers ; Hubert H. FernandezSource :
- Movement Disorders [ 0885-3185 ] ; 2007-01.
English descriptors
Abstract
We studied the relationship between two screening cognitive measures and off motor Unified Parkinson's Disease Rating Scale (UPDRS) scores in 108 Parkinson's disease patients. Multiple regressions were conducted to examine the UPDRS subscores' unique contributions to cognitive function. When including bradykinesia, rigidity, and postural/gait instability subscores, only bradykinesia predicted Mini Mental Status Examination (MMSE), normalized β = −0.57, t(104) = −3.31, P < 0.01, and Dementia Rating Scale‐2 (DRS‐2), normalized β = −0.45, t(104) = −2.55, P < 0.05. Tremor was not included in the regression analyses because it did not correlate with cognitive function. When including axial and appendicular subscores, only the axial subscore predicted MMSE, normalized β = −0.39, t(105) = −3.19, P < 0.01, and DRS‐2 scores, normalized β = −0.40, t(106) = −3.28, P < 0.01. When including left‐sided and right‐sided subscores, only the right‐sided symptoms predicted DRS‐2 scores, normalized β = −0.28, t(105) = −2.45, P < 0.05, and showed a trend toward predicting MMSE scores, normalized β = −0.22, t(105) = −1.95, P = 0.054. We therefore found that right‐sided symptoms (for laterality), axial symptoms (for region), and bradykinesia (for type of symptoms) were thebest predictors of cognitive function. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.21220
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Crucian</name><affiliation><mods:affiliation>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S." last="Okun">Michael S. Okun</name><affiliation><mods:affiliation>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Rodriguez, Ramon L" sort="Rodriguez, Ramon L" uniqKey="Rodriguez R" first="Ramon L." last="Rodriguez">Ramon L. Rodriguez</name><affiliation><mods:affiliation>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Skidmore, Frank M" sort="Skidmore, Frank M" uniqKey="Skidmore F" first="Frank M." last="Skidmore">Frank M. 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Williams</name><affiliation><mods:affiliation>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Seignourel, Paul" sort="Seignourel, Paul" uniqKey="Seignourel P" first="Paul" last="Seignourel">Paul Seignourel</name><affiliation><mods:affiliation>Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Crucian, Gregory P" sort="Crucian, Gregory P" uniqKey="Crucian G" first="Gregory P." last="Crucian">Gregory P. Crucian</name><affiliation><mods:affiliation>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S." last="Okun">Michael S. Okun</name><affiliation><mods:affiliation>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Rodriguez, Ramon L" sort="Rodriguez, Ramon L" uniqKey="Rodriguez R" first="Ramon L." last="Rodriguez">Ramon L. Rodriguez</name><affiliation><mods:affiliation>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Skidmore, Frank M" sort="Skidmore, Frank M" uniqKey="Skidmore F" first="Frank M." last="Skidmore">Frank M. Skidmore</name><affiliation><mods:affiliation>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Foster, Paul S" sort="Foster, Paul S" uniqKey="Foster P" first="Paul S." last="Foster">Paul S. 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Multiple regressions were conducted to examine the UPDRS subscores' unique contributions to cognitive function. When including bradykinesia, rigidity, and postural/gait instability subscores, only bradykinesia predicted Mini Mental Status Examination (MMSE), normalized β = −0.57, t(104) = −3.31, P < 0.01, and Dementia Rating Scale‐2 (DRS‐2), normalized β = −0.45, t(104) = −2.55, P < 0.05. Tremor was not included in the regression analyses because it did not correlate with cognitive function. When including axial and appendicular subscores, only the axial subscore predicted MMSE, normalized β = −0.39, t(105) = −3.19, P < 0.01, and DRS‐2 scores, normalized β = −0.40, t(106) = −3.28, P < 0.01. When including left‐sided and right‐sided subscores, only the right‐sided symptoms predicted DRS‐2 scores, normalized β = −0.28, t(105) = −2.45, P < 0.05, and showed a trend toward predicting MMSE scores, normalized β = −0.22, t(105) = −1.95, P = 0.054. We therefore found that right‐sided symptoms (for laterality), axial symptoms (for region), and bradykinesia (for type of symptoms) were thebest predictors of cognitive function. © 2006 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Lindsy N. Williams BS</name><affiliations><json:string>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</json:string></affiliations></json:item><json:item><name>Paul Seignourel MS</name><affiliations><json:string>Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA</json:string></affiliations></json:item><json:item><name>Gregory P. Crucian PhD</name><affiliations><json:string>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</json:string></affiliations></json:item><json:item><name>Michael S. 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Jacobson IV BS</name><affiliations><json:string>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</json:string></affiliations></json:item><json:item><name>Janet Romrell PA‐C</name><affiliations><json:string>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</json:string></affiliations></json:item><json:item><name>Dawn Bowers PhD</name><affiliations><json:string>Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA</json:string></affiliations></json:item><json:item><name>Hubert H. 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Multiple regressions were conducted to examine the UPDRS subscores' unique contributions to cognitive function. When including bradykinesia, rigidity, and postural/gait instability subscores, only bradykinesia predicted Mini Mental Status Examination (MMSE), normalized β = −0.57, t(104) = −3.31, P > 0.01, and Dementia Rating Scale‐2 (DRS‐2), normalized β = −0.45, t(104) = −2.55, P > 0.05. Tremor was not included in the regression analyses because it did not correlate with cognitive function. When including axial and appendicular subscores, only the axial subscore predicted MMSE, normalized β = −0.39, t(105) = −3.19, P > 0.01, and DRS‐2 scores, normalized β = −0.40, t(106) = −3.28, P > 0.01. When including left‐sided and right‐sided subscores, only the right‐sided symptoms predicted DRS‐2 scores, normalized β = −0.28, t(105) = −2.45, P > 0.05, and showed a trend toward predicting MMSE scores, normalized β = −0.22, t(105) = −1.95, P = 0.054. We therefore found that right‐sided symptoms (for laterality), axial symptoms (for region), and bradykinesia (for type of symptoms) were thebest predictors of cognitive function. © 2006 Movement Disorder Society</abstract><qualityIndicators><score>5.783</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1341</abstractCharCount><pdfWordCount>3383</pdfWordCount><pdfCharCount>22126</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>200</abstractWordCount></qualityIndicators><title>Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's 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type="degree">PhD</roleName><affiliation>Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA</affiliation></author><author><persName><forename type="first">Hubert H.</forename><surname>Fernandez</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Department of Neurology, McKnight Brain Institute/University of Florida, P.O. 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Multiple regressions were conducted to examine the UPDRS subscores' unique contributions to cognitive function. When including bradykinesia, rigidity, and postural/gait instability subscores, only bradykinesia predicted Mini Mental Status Examination (MMSE), normalized β = −0.57, t(104) = −3.31, P < 0.01, and Dementia Rating Scale‐2 (DRS‐2), normalized β = −0.45, t(104) = −2.55, P < 0.05. Tremor was not included in the regression analyses because it did not correlate with cognitive function. When including axial and appendicular subscores, only the axial subscore predicted MMSE, normalized β = −0.39, t(105) = −3.19, P < 0.01, and DRS‐2 scores, normalized β = −0.40, t(106) = −3.28, P < 0.01. When including left‐sided and right‐sided subscores, only the right‐sided symptoms predicted DRS‐2 scores, normalized β = −0.28, t(105) = −2.45, P < 0.05, and showed a trend toward predicting MMSE scores, normalized β = −0.22, t(105) = −1.95, P = 0.054. We therefore found that right‐sided symptoms (for laterality), axial symptoms (for region), and bradykinesia (for type of symptoms) were thebest predictors of cognitive function. © 2006 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>motor</term></item><item><term>cognition</term></item><item><term>dementia</term></item><item><term>bradykinesia</term></item><item><term>postural instability</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2005-12-21">Received</change><change when="2006-07-31">Registration</change><change when="2007-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/421E88E8B5E5AB517C9E5E69EDBDDC431764B9EC/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="120"><doi origin="wiley" registered="yes">10.1002/mds.v22:1</doi><numberingGroup><numbering type="journalVolume" number="22">22</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2007-01">January 2007</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="250" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.21220</doi><idGroup><id type="unit" value="MDS21220"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="articleCategory">Brief Report</title><title type="tocHeading1">Brief Reports</title></titleGroup><copyright ownership="thirdParty">Copyright © 2006 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2005-12-21"></event><event type="manuscriptRevised" date="2006-07-17"></event><event type="manuscriptAccepted" date="2006-07-31"></event><event type="firstOnline" date="2006-11-06"></event><event type="publishedOnlineFinalForm" date="2007-01-22"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2006-11-06"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.4.7 mode:FullText source:FullText result:FullText" date="2011-02-24"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">141</numbering><numbering type="pageLast">144</numbering></numberingGroup><correspondenceTo>Department of Neurology, McKnight Brain Institute/University of Florida, P.O. Box 100236, Gainesville, FL 32610</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS21220.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="16"></count><count type="wordTotal" number="2898"></count></countGroup><titleGroup><title type="main" xml:lang="en">Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease</title><title type="short" xml:lang="en">Motor Dysfunction and Cognitive Impairment</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Lindsy N.</givenNames><familyName>Williams</familyName><degrees>BS</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Paul</givenNames><familyName>Seignourel</familyName><degrees>MS</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Gregory P.</givenNames><familyName>Crucian</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Michael S.</givenNames><familyName>Okun</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Ramon L.</givenNames><familyName>Rodriguez</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Frank M.</givenNames><familyName>Skidmore</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Paul S.</givenNames><familyName>Foster</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Charles E.</givenNames><familyName>Jacobson</familyName><nameSuffix>IV</nameSuffix><degrees>BS</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Janet</givenNames><familyName>Romrell</familyName><degrees>PA‐C</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Dawn</givenNames><familyName>Bowers</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Hubert H.</givenNames><familyName>Fernandez</familyName><degrees>MD</degrees></personName><contactDetails><email>fernandez@neurology.ufl.edu</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">motor</keyword><keyword xml:id="kwd3">cognition</keyword><keyword xml:id="kwd4">dementia</keyword><keyword xml:id="kwd5">bradykinesia</keyword><keyword xml:id="kwd6">postural instability</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We studied the relationship between two screening cognitive measures and <i>off</i> motor Unified Parkinson's Disease Rating Scale (UPDRS) scores in 108 Parkinson's disease patients. Multiple regressions were conducted to examine the UPDRS subscores' unique contributions to cognitive function. When including bradykinesia, rigidity, and postural/gait instability subscores, only bradykinesia predicted Mini Mental Status Examination (MMSE), normalized β = −0.57, t(104) = −3.31, <i>P</i> < 0.01, and Dementia Rating Scale‐2 (DRS‐2), normalized β = −0.45, t(104) = −2.55, <i>P</i> < 0.05. Tremor was not included in the regression analyses because it did not correlate with cognitive function. When including axial and appendicular subscores, only the axial subscore predicted MMSE, normalized β = −0.39, t(105) = −3.19, <i>P</i> < 0.01, and DRS‐2 scores, normalized β = −0.40, t(106) = −3.28, <i>P</i> < 0.01. When including left‐sided and right‐sided subscores, only the right‐sided symptoms predicted DRS‐2 scores, normalized β = −0.28, t(105) = −2.45, <i>P</i> < 0.05, and showed a trend toward predicting MMSE scores, normalized β = −0.22, t(105) = −1.95, <i>P</i> = 0.054. We therefore found that right‐sided symptoms (for laterality), axial symptoms (for region), and bradykinesia (for type of symptoms) were thebest predictors of cognitive function. © 2006 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Motor Dysfunction and Cognitive Impairment</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Lindsy N.</namePart><namePart type="family">Williams</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul</namePart><namePart type="family">Seignourel</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gregory P.</namePart><namePart type="family">Crucian</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael S.</namePart><namePart type="family">Okun</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ramon L.</namePart><namePart type="family">Rodriguez</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Frank M.</namePart><namePart type="family">Skidmore</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul S.</namePart><namePart type="family">Foster</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Charles E.</namePart><namePart type="family">Jacobson IV</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Janet</namePart><namePart type="family">Romrell</namePart><namePart type="termsOfAddress">PA‐C</namePart><affiliation>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dawn</namePart><namePart type="family">Bowers</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hubert H.</namePart><namePart type="family">Fernandez</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA</affiliation><description>Correspondence: Department of Neurology, McKnight Brain Institute/University of Florida, P.O. Box 100236, Gainesville, FL 32610</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-01</dateIssued><dateCaptured encoding="w3cdtf">2005-12-21</dateCaptured><dateValid encoding="w3cdtf">2006-07-31</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">1</extent><extent unit="references">16</extent><extent unit="words">2898</extent></physicalDescription><abstract lang="en">We studied the relationship between two screening cognitive measures and off motor Unified Parkinson's Disease Rating Scale (UPDRS) scores in 108 Parkinson's disease patients. Multiple regressions were conducted to examine the UPDRS subscores' unique contributions to cognitive function. When including bradykinesia, rigidity, and postural/gait instability subscores, only bradykinesia predicted Mini Mental Status Examination (MMSE), normalized β = −0.57, t(104) = −3.31, P < 0.01, and Dementia Rating Scale‐2 (DRS‐2), normalized β = −0.45, t(104) = −2.55, P < 0.05. Tremor was not included in the regression analyses because it did not correlate with cognitive function. When including axial and appendicular subscores, only the axial subscore predicted MMSE, normalized β = −0.39, t(105) = −3.19, P < 0.01, and DRS‐2 scores, normalized β = −0.40, t(106) = −3.28, P < 0.01. When including left‐sided and right‐sided subscores, only the right‐sided symptoms predicted DRS‐2 scores, normalized β = −0.28, t(105) = −2.45, P < 0.05, and showed a trend toward predicting MMSE scores, normalized β = −0.22, t(105) = −1.95, P = 0.054. We therefore found that right‐sided symptoms (for laterality), axial symptoms (for region), and bradykinesia (for type of symptoms) were thebest predictors of cognitive function. © 2006 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>motor</topic><topic>cognition</topic><topic>dementia</topic><topic>bradykinesia</topic><topic>postural instability</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>141</start><end>144</end><total>4</total></extent></part></relatedItem><identifier type="istex">421E88E8B5E5AB517C9E5E69EDBDDC431764B9EC</identifier><identifier type="DOI">10.1002/mds.21220</identifier><identifier type="ArticleID">MDS21220</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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